The brothers capture a female vampire named Lucy who has no idea how she became one, which leads them to Dixon, a male vampire who is a little too giving. Gordon returns with a vengeance leaving Sam in danger.

In this Christmas-themed episode, Sam and Dean follow the trail of an "anti-Santa" that abducts its victims by using their chimneys. Dean tries to get Sam to celebrate Christmas like they used to but Sam doesn't want to accept that it could be the last one they'll spend together.

Ronon Dex is captured by Tyre, who wants to hand him to the Wraith in order to maintain his role in their circle. However, when the deal turns sour, and Tyre is left for dead, the Atlantis expedition persuade him to take back their friend. Meanwhile, The Wraith turn Ronon into a Wraith worshipper.

The seemingly harmless practices of a group of neighborhood witches goes bad when one of them kills a woman. Ruby offers her assistance... but she has a few secrets of her own.

Hancock is a down-and-out superhero who's forced to employ a PR expert to help repair his image when the public grows weary of all the damage he's inflicted during his lifesaving heroics. The agent's idea of imprisoning the antihero to make the world miss him proves successful, but will Hancock stick to his new sense of purpose or slip back into old habits?