A young couple, struggling to buy a first home, think their prayers are answered when a distant relative bequeaths them a vast country house. The catch? It’s riddled with ghosts…

When the ghostly visions return to haunt Alison, Mike must reassure her that there is a rational, medical explanation – a comforting theory about which he could not be more wrong.

A car plows through a crowd outside of a concert venue and is followed by gunfire, sparking fears that it may be terror-related. Burgess spots Atwater's brother where he shouldn't be. The team works to bring peace to the community before more blood is shed.

As Section Chief Blevins expresses his concern with the direction of the X-Files, Mulder becomes obsessed with solving a case that closely parallels an encounter he experienced as a child - the abduction of his kid sister, Samantha.

Several patients are discovered to have the same rare infection, prompting Dr. Charles' daughter Robyn, an epidemiologist, to be brought in to find the common link. Dr. Choi and Dr. Rhodes work on an elderly man who is discovered to be very ill, but a conflict in how to best treat him develops between his son and his young girlfriend. Meanwhile, Dr. Reese tries to help a young drug addict and Maggie tends to a patient who is dear to her heart.