The Phoenix teams up with a woman who’s a soccer mom by day but a master thief by night to catch one of her contacts, an underworld criminal, who has hired her to steal a dirty bomb.

Mac and Jack hit the road for a weekend of relaxation in Las Vegas, but their mini-vacation is cut short when someone from their past abducts them and locks them in a concrete room. Also, Matty tasks Riley, Bozer and Leanna with stealing a diamond encoded with terrorist intel from a princess in Milan.

Matty reveals a shocking secret to the team: she has a husband who’s been undercover in a criminal organization called S-Company for eight years. When his status as a CIA agent comes out, Matty needs MacGyver to find and extract her husband before it’s too late.

When a vial containing a deadly virus is stolen from the Center for Disease Control in Atlanta, MacGvyer and team race to recover it before the thief unleashes a global pandemic.

MacGyver and the team set off on a dangerous capture operation after an Irish military intelligence officer approaches them claiming to know the whereabouts of “The Ghost,” a lethal bomb maker whom Mac has been hunting for years.

Matty sends MacGyver and team to Ghana to recover a hard drive from an e-waste landfill that is run by a powerful and violent man. But when Matty refuses to reveal what’s on the drive, other than a mysterious file called “Dragonfly,” the team speculates about what could be so important to her.

Murdoc abducts MacGyver’s girlfriend, Nasha, to force Mac to help him rescue his son, Cassian, from a kidnapper. Also, a dangerous individual from Murdoc’s personal life shows up, giving Mac a glimpse into the villain’s past.

When Oversight’s attempt to capture a drug cartel’s leader goes bad, MacGyver and Jack rush to Mexico to pull their boss out while racing through the heart of the country during Dia de Muertos celebrations. Also, Bozer and Riley use Halloween as a distraction to gather intel on a man accused of treason.

MacGyver and Riley, with the help of Vasil, a distraught father, must find a way to drive a tanker filled with liquid oxygen through a region occupied by rebels and deliver it to a children’s hospital before they run out. Also, Riley helps MacGyver decide whether or not to allow his father back into his life.

MacGyver, Riley, Bozer and Leanna go undercover on a college campus to smoke out a deep-cover operative who is recruiting students to carry out deadly attacks around the world. Also, Jack joins bounty hunter Billy Colton in the hunt for a bail jumper but is concerned when he finds out Billy offered Riley a job.