Supergirl is joined by familiar faces from the past to help her stop Lex and Nyxly for good. Meanwhile, Alex and Kelly prepare to walk down the aisle.

Supergirl and the super friends take drastic action after a loved one is kidnapped by Nyxly and Lex. An unlikely ally steps in to help the team.

Supergirl is determined to keep everyone safe from Lex and Nyxly so she doubles down on patrol, especially as Alex and Kelly’s bachelorette party is coming up. Alex is torn between duty and finally allowing herself the time to enjoy her new family. Brainy receives heartbreaking news, and William clashes with Andrea over her recent coverage of Lex.

When Lex Luthor appears by Nyxly’s side, Supergirl and team must deal with the emotional fallout of facing their two biggest foes at the same time. Alex makes plans for the perfect proposal to Kelly, but work keeps getting in the way.

Kara lands her dream story for Catco but when the city is suddenly attacked by a nightmare monster at the same time as her interview, she is forced to take a serious look at her life and decide if she can continue to live as both Kara and Supergirl. As Dreamer takes the lead on the search for the Dream Totem, which can vanquish they nightmare monster in National City, she realizes she needs to ask her sister Maeve for help.

Supergirl continues to fight Nyxly for the remaining totems but after Nyxly kidnaps William, Supergirl realizes she needs to take a more proactive stance to keep National City safe. Meanwhile, Alex faces the biggest challenge of her life.

Lena is uncertain about using her magical abilities to help Supergirl retrieve the second totem from Nyxly. William struggles to write a story on the Super Friends that makes both the heroes and Andrea happy. Meanwhile, Kelly is thrilled Esme has found a new home, but things go awry and the little girl’s future is put in danger.

Supergirl and team race Nyxly for control of a magical totem that controls courage. Supergirl and Nyxly battle and each get a piece of the totem but learn the first person to pass the test of courage will gain control of the entire thing. Meanwhile, Lena is still struggling to make sense of her newfound gift.

Kelly is horrified when the Ormfell building implodes, injuring many in the community, including Joey. However, her horror quickly turns to frustration when she realizes that the hospital is overwhelmed, people are getting sicker, and no one is coming to help – including Supergirl who is busy fighting Nyxly. Knowing that she can make a difference, Kelly embraces her power and fully steps into her role as Guardian. Joined by Supergirl, Alex, Diggle and team, Guardian leads the way to restoring justice to the fallen community.

Supergirl and team must stop Nyxly from vanquishing a familiar face from Supergirl’s past – Mr. Mxyzptlk. Mxy returns and explains Nyxly’s dark history to the super team in the best way he knows how – in song form. Meanwhile, Lena visits her mother’s birthplace in Newfoundland, eager to dig into her past but is shocked by the small town’s icy reception towards her.